Effects of fluorine substitution of cytosine analogues on the binding affinity to HIV-1 reverse transcriptase

Bioorg Med Chem Lett. 2004 Jan 19;14(2):437-40. doi: 10.1016/j.bmcl.2003.10.042.

Abstract

In order to find out the possible role of fluorine substituent in binding of the fluorinated cytidine analogues at the active site of HIV-1 RT, binding modes of several 5-fluoro cytidine analogues, such as FTC, D-dioxolane 5-FC and D-2'F-d4FC to the active site of HIV-1 reverse transcriptase, were compared by molecular dynamics studies.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Binding Sites
  • Cytosine / chemistry*
  • Cytosine / metabolism*
  • Fluorine / chemistry*
  • Fluorine / metabolism*
  • HIV Reverse Transcriptase / metabolism*

Substances

  • Fluorine
  • Cytosine
  • HIV Reverse Transcriptase